鲍凌志 副教授
博士,副教授,硕士生导师。主要从事预防医学教学、科研工作。主持参与国家自然科学基金、安徽自然科学基金、安徽省高校自然科学研究重大项目、重点项目等。发表SCI论文20余篇。
研究方向:卫生毒理与卫生检验
邮箱:20200002@wnmc.edu.cn
电话:18356087101
受教育和工作经历:
2020-01 至今,皖南医学院,公共卫生学院,副教授,硕士生导师
2011-11 至 2019-12,中科院合肥物质科学研究院,副研究员
2009-05 至 2011-10,美国堪萨斯大学,博士后
2003-09 至 2008-12,中国科学院合肥物质科学研究院,生物物理专业,博士
近五年主持和参与的科研项目:
1.基于人源肺类器官的江淮地区PM2.5和03等大气污染物健康效应及其机制研究,国家自然科学基金区域创新发展联合基金子课题,2023-2026,260万,参与.
2.安徽高校自然科学研究项目,重大项目,重金属铅细菌生物传感器的构建及在卫生检验中的应用, 2023-8至2026-7,20万元,主持。
3.信息材料与智能感知安徽省实验室开放课题,重点项目,2023-1至2025-1,5万元,主持。
4.安徽高校自然科学研究项目,重点项目,Nrf2-HO-1信号轴在电离辐射适应性效应中的作用及机制研究,2020-11至2022-11,6万元,主持。
5.皖南医学院博士启动基金,50万元,2020-2024,主持。
发表的代表性论文:
1.Shunlan Li, Dongdong Chen, Ziqing Liu, Shipin Tao, Tianyi Zhang, Yiwen Chen, Lingzhi Bao, Jie Ma, Yuee Huang, Shengmin Xu, Lijun Wu, Shaopeng Chen*. Directed evolution of TetR for constructing sensitive and broad-spectrum tetracycline antibiotics whole-cell biosensor. J Hazard Mater. 2023 Aug 14; 460: 132311. doi: 10.1016/j.jhazmat.2023.132311. (中科院一区SCI,IF=13.6)
2.Lingzhi Bao, Aizhen Yang, Ziqing Liu, Jie Ma, Jiajie Pan, Yi Zhu, Ying Tang, Pu Dong, Guoping Zhao & Shaopeng Chen*. Development of a mammalian cell-based ZZ display system for IgG quantification. BMC Biotechnology. 2023 July 28, 23: 24. (中科院三区SCI, IF=3.5)
3.Dongdong Chen, Shengmin Xu*, Shunlan Li, Shipin Tao, Luzhi Li, Shaopeng Chen*, Lijun Wu. Directly Evolved AlkS-Based Biosensor Platform for Monitoring and High-Throughput Screening of Alkane Production. ACS Synth Biol. 2023 Mar 17; 12(3,): 832–841 (中科院二区SCI,IF=5.25)
4.Tao Wu, Shengmin Xu, Biao Chen, Lingzhi Bao, Jie Ma, Wei Han, An Xu, Kwan Ngok Yu, Lijun Wu & Shaopeng Chen*. Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation. Nanotoxicology, 2022, 16 (6-8): 757-775. (中科院二区SCI,IF=5.0)
5.Yeshen Cai, Kaili Zhu, Liang Shen, Jie Ma, Lingzhi Bao, Dongdong Chen, Liangchen Wei, Nan Wei, Binmei Liu, Yuejin Wu, and Shaopeng Chen*. Evolved Biosensor with High Sensitivity and Specificity for Measuring Cadmium in Actual Environmental Samples. Environ Sci Technol. 2022 Jul 19, 56(14):10062-10071. (中科院一区SCI,IF=11.56)
6.Bao Lingzhi, Ma Jie, Cheng Guodong, Hou Jue, Hei Tom K, Yu KN, Han Wei, Role of heme oxygenase-1 in low dose radioadaptive response, Redox Biology, 2016, 8: 333-340. Redox Biology. (中科院一区SCI,IF=11.4)
7.Song Wencheng, Wang Enjun, Gao Ying, Wu Qibing, Rao Shenghong, Wang Hongzhi, Bao Lingzhi, Low temperature plasma induced apoptosos in CNE-2Z cells through endoplasmic reticulum stress and mitochondrial dysfunction pathways, Plasma Processes and Polymers, 2018. e1600249. (中科院二区SCI,IF=3.88)
8.Bao Lingzhi, Xu An, Chen Shaopeng, Zhu Lingyan, Zhao Ye, Zhao Guoping, Jiang Erkang, Wang Jun. Activated Genotoxicity of Diesel Particulate Extract by Ultraviolet A Radiation in Mammalian Cells: Role of Singlet Oxygen. Environmental Health Perspectives. 2009. 117(3):436-41. (中科院一区SCI,IF=11.04)
9.Jie Ma, Hao Zhang, Cheng Cheng, Jie Shen, Lingzhi Bao*, Wei Han*, Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage,Plasma Processes and Polymers,2016. ppap. 201600162: 1-12(中科院二区SCI,IF=3.88,共同通讯)
10.Jue Hou, Jie Ma, KN Yu, Wei Li, Chen Cheng, Lingzhi Bao*, Wei Han*, Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells, BMC Genomics, 2015, 16: 435-435,(中科院二区SCI,IF=4.4,共同通讯)
11.Wencheng Song, Enjun Wang, Ying Gao, Qibing Wu, Shenghong Rao, Hongzhi Wang, Lingzhi Bao*, Low temperature plasma induced apoptosos in CNE-2Z cells through endoplasmic reticulum stress and mitochondrial dysfunction pathways, Plasma Processes and Polymers, 2017. e1600249. IF=3.173,(中科院二区SCI,IF=3.88,通讯)
12.Lingzhi Bao, Honglian Shi. Potential molecular mechanisms for combined toxicity of arsenic and alcohol. Journal of Inorganic Biochemistry. 2010. 104(12):1229-33(中科院二区SCI,IF=4.34)
13.Lingzhi Bao, Honglian Shi. Arsenite induces endothelial cell permeability increase through a ROS-VEGF pathway. Chemical Research in Toxicology. 2010. 23(11):1726-34 (中科院二区SCI,IF=4.1)
14.Lingzhi Bao, An Xu, Shaopeng Chen, Lingyan Zhu, Ye Zhao, Guoping Zhao, Erkang Jiang, Jun Wang. Activated Genotoxicity of Diesel Particulate Extract by Ultraviolet A Radiation in Mammalian Cells: Role of Singlet Oxygen. Environmental Health Perspectives. 2009. 117(3):436-41(中科院一区SCI,IF=11.4)
15.Lingzhi Bao, Shaopeng Chen, Lijun Wu, Tom K. Hei, Yuejin Wu, Zengliang Yu, and An Xu. Mutagenicity of diesel exhaust particles mediated by cell-particle interaction in mammalian cells. Toxicology. 2007. 229:91-100. (中科院二区SCI,IF=4.5)
申请的专利:
1.陈少鹏,朱凯丽,赵国平,鲍凌志,马洁。一种用于检测汞的可视化生物传感器及其应用,申请号:202311093583.2,受理日期:2023年08月29日
2.陈少鹏,沈亮,陈伊雯,鲍凌志,马洁。一种镉离子诱导型操纵子突变体、重组载体及其应用,申请号:202310393070.7,受理日:2023年04月13日
3.鲍凌志,潘家洁,杨爱珍,马洁,赵国平,陈少鹏。哺乳动物细胞表面展示质粒、细胞系及抗体检测方法、高产抗体细胞株的检测方法及应用,申请号:202310204624.4,受理日期:2023年03月06日
4.陈少鹏,蔡叶申,朱凯丽,沈亮,鲍凌志。一种CadR基因突变体、含突变体的重组载体及其应用,申请号:20211435335.2,受理日期:2021年11月29日