韩丽媛-公共卫生学院

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韩丽媛

时间：2026-01-04 预审：罗文杰二审：张筱婕终审：李康才来源：公共卫生学院阅读次数：

【教育经历】

1.2007-09至2012-07，哈尔滨医科大学，硕博连读

2.2003-09至2007-07，山东省第二医科大学，本科

【工作经历】

1.2020-07至今，宁波市第二医院（国科宁波生命与健康产业研究院），心脑血管流行病学与转化医学中心主任

2.2015-06至2019-04，苏州大学，公共卫生与预防医学学科博士后

3.2016-06至2017-06，美国杜兰大学，访问学者

4.2012-07至2020-07，宁波大学，预防医学系教师

【科研项目】

1.国家自然科学基金面上项目、基于集成学习算法的急性大血管闭塞性脑卒中诊断模型构建与应用研究（82173648）、2022-2025、60万、在研、主持。

2.浙江省公益技术应用研究项目、肠道菌群代谢物TMAO及其前体物与缺血性脑卒中复发预测模型构建研究（LGC22H260005）、2022-2024、10万、在研、主持。

3.宁波市自然科学基金重点项目、基于人工智能算法的脑卒中诊断模型研究（2022J271）、2022.9-2025.8、30万、在研、主持。

4.国家科技部项目重点研发计划、“脑血管病临床研究大数据与生物样本库平台构建和关键技术研究”项目中的“基于全国大规模队列和区域信息化的脑血管病大数据仓库及分析平台建设”（ 2017YFC1310902）、2017-2020、39万、结题、主持。

5.国家科技部项目重点研发计划、“重大慢性非传染性疾病防控研究”专项“重大慢性病疾病负担及防控策略研究”（ 2018YFC1315305）、2018-2020、38万、结题、主持。

6.浙江省自然科学基金面上项目、DNA甲基化调控缺血性脑卒中的发病机制研究、（LY17H260002）、2017-2019、10万、结题、主持。

7.浙江省医药卫生科技计划、Hcy代谢关键酶基因DNA羟甲基化调控IS的发病机制研究（2021RC028）、2021-2023、6万、结题、主持。

【主要论著】

1. Liyuan Han^#, Dingyun You^#, Xuping Gao, Shiwei Duan, Guoqing Hu, Haidong Wang, Shiwei Liu, Fangfang Zeng^*. Unintentional injuries and violence among adolescents aged 12-15 years in 68 low-income and middle-income countries: a secondary analysis of data from the Global School-Based Student Health Survey. Lancet Child Adolesc Health, 2019, 3(9): 616-626. ( SCI一区, IF=19.9)

2. Liyuan Han^#, Dingyun You, Wenjie Ma, Astell-Burt Thomas, Xiaoqi Feng, Shiwei Duan, Lu Qi^*. National Trends in American Heart Association Revised Life's Simple 7 Metrics Associated with Risk of Mortality Among US Adults. JAMA Netw Open. 2019, 2(10): e1913131. (SCI一区, IF=10.5)

3. Bizhong Che, Chongke Zhong, Ruijie Zhang, Liyuan Pu, Tian Zhao, Yonghong Zhang^* and Liyuan Han^*. Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors:an analysis of UK biobank data. Cardiovascular Diabetology. 2023 Feb 16;22(1):34. （SCI一区，IF=8.5）

4. Liyuan Pu, Li Wang , Ruijie Zhang , Tian Zhao , Yannan Jiang，Liyuan Han^*. Projected Global Trends in Ischemic Stroke Incidence, Deaths and Disability-Adjusted Life Years from 2020 to 2030. Stroke. 2022.10.14. (SCI一区, IF=7.8)

5. Ruijie Zhang, Huina Liu, Liyuan Pu, Tian Zhao, Shun Zhang，Kun Han^*,Liyuan Han^*. The global burden of ischemic stroke in young adults in 204 countries and territories. Neurology. 2022. (SCI一区, IF=7.7)

6. Quanquan Ding, Shiwei Liu, Yindan Yao, Huina Liu, Ting Cai, Liyuan Han^*. Global, regional and national burden of ischemic stroke, 1990-2019. Neurology.2021. (SCI一区, IF=7.7)

7. Jingjing Liu, Qunhong Wu^*, Yanhua Hao, Mingli Jiao, Xing Wang, Shengchao Jiang, Liyuan Han^*. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021, Jan 27. (SCI一区, IF=6.0)

8. Guodong Xu^#, Dingyun You^#, Liping Wong^#, Donghui Duan, Fanqian Kong, Xiaohong Zhang, Jinshun Zhao, Wenhua Xing^*, Liyuan Han^*, Li Li^*. Risk of all-cause and CHD mortality in women versus men with type 2 diabetes. Eur. J. Endocrinol. 2019, 180(4): 243-255. (SCI一区, IF=5.3)

9. Dingyun You^#, Liyuan Han^#, Jingjing Liu, Lian Li, Qunhong Wu^*, Fangfang Zeng^*. Trends in long-term cardiovascular and renal burdens of the 2017 clinical practice guideline for hypertension in US adults, 1998-2016. Eur J Prev Cardiol, 2019, Nov 23. (SCI二区, IF=8.4)

10. Binbin Lin^#, Hui Cheng^#, Yuanyan Dou, Minglan Jiang, Zhennan Lin, Qinghua Ma, Congju Wang, Yong Xu, Yana Ma, Hongpeng Sun^*, Liyuan Han^*. Cardiovascular disease burden of Chinese middle-aged and elderly people across the spectrum of glycaemia levels. Eur J Prev Cardiol, 2019, Aug 19. (SCI二区, IF=8.4)

11. Lian Li^#, Dingyun You^#, Tiecheng Ruan, Shujun Xu, Duo Mi^*, Ting Cai^*, Liyuan Han^* The prevalence of suicidal behaviors and their mental risk factors among young adolescents in 46 low- and middle-income countries. J Affect Disord. 2021, 281: 847-855. (SCI二区, IF=4.9)

12. Tian Zhao, Shiwei Liu, Ruijie Zhang, Zhenping Zhao, Hu Yu, Liyuan Pu, Li Wang^*, Liyuan Han^*.Global Burden of Vitamin A Deficiency in 204 Countries and Territories from 1990-2019. Nutrients. 2022.（SCI二区，IF=4.8）

13. Liyuan Han^#, Tian Zhao, Ruijie Zhang, Yanhua Hao, Mingli Jiao, Qunhong Wu, Jingjing Liu, Maigeng Zhou. Burden of Nutritional Deficiencies in China: Findings from the Global Burden of Disease Study 2019. Nutrients.2022.10. (SCI二区, IF=4.8)

14. Yi Huang, Yongan Li, Haiyan Pan, Liyuan Han^*. Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide. J Glob Health. 2023 Nov 29;13:04160. （SCI三区，IF=4.5）

15. Liyuan Han^#, Tao Zhang, Dingyun You, Wei Chen, George Bray, Frank Sack,Lu Qi. Temporal and mediation relations of weight loss, and changes in insulin resistance and blood pressure in response to 2-year weight-loss diet interventions: the POUNDS Lost trial. European journal of nutrition. 2022.2.1. (SCI二区, IF=4.1)

16. Che Bizhong, Zhong Chongke, Zhang Ruijie, Wang Meng, Zhang Yonghong, Han Liyuan^*. Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data. EUROPEAN JOURNAL OF NUTRITION. 2022.（SCI二区，IF=4.1）

17. Liyuan Pu, Ruijie Zhang, Xiaojie Wang, Tian Zhao, Hongpeng Sun, Han Liyuan^*. Associations of Serum Biomarkers of Fruit and Vegetable Intake with the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study. Front Nutr.2022. （SCI二区，IF=4.0）

18. Rong-Rong Zhu, Xu-Ping Gao, Min-Qi Liao, Yun-Feng Cui, Si-Xian Tan, Fang-Fang Zeng, Yan-Mei Lou, Chang-Yi Wang, Shan Xu, Xiao-Lin Peng, Shu-Hong Dai, Dan Zhao, Li Wang, Zhao Ping, Xiao-Yu Dai, Pin-Ning Feng, Li-Yuan Han^*. Non-alcoholic Fatty Liver Disease Is Associated with Aortic Calcification: A Cohort Study with Propensity Score Matching. Front Endocrinol (Lausanne).2022.5.16. （SCI二区，IF=3.9）

19. Tian Zhao, Jingjing Zeng, Ruijie Zhang, Weinv Fan, Qiongfeng Guan, Han Wang, Liyuan Pu, Yannan Jiang, Huiqun Yang, Xiaokun Wang, Liyuan Han^*. Serum Olink proteomics-based identification of protein biomarkers associated with the immune response in ischemic stroke, Journal of Proteome Research.2024 Mar 1;23(3):1118-1128. （SCI二区，IF=3.8）

20. Liyuan Han^#, Chang Chen^#, Xingyu Lu, Yanqun Song, Zhou Zhang, Chang Zeng, Rudyard Chiu, Li Li, Miao Xu, Chuan He, Wei Zhang^*, Shiwei Duan^*. Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes. Genomics. 2021, 113: 79-87. (SCI二区, IF=3.4)

21. Bei Zhang, Liyuan Pu, Tian Zhao, Li Wang, Chang Shu, Shan Xu, Jing Sun, Ruijie Zhang, Liyuan Han^*. Global burden of cardiovascular disease from 1990 to 2019 attributable to dietary factors. J Nutr. 2023 Mar 30;S0022-3166(23)35504-4.（SCI三区，IF=3.7）

22. Tian Zhao, Jingjing Zeng, Ruijie Zhang, Liyuan Pu, Han Wang, Lifang Pan, Yannan Jiang, Xiaoyu Dai, Yuyi Sha, Liyuan Han^*.Proteomic advance of ischemic stroke: preclinical, clinical, and intervention. Metab Brain Dis. 2023 Dec;38(8):2521-2546.（SCI三区，IF=3.2）

23. Tian Zhao, Qianqian Yan, Changyi Wang, Jingjing Zeng, Ruijie Zhang, Han Wang, Liyuan Pu, Xiaoyu Dai, Huina Liu, Liyuan Han^*. Identification of Serum Biomarkers of Ischemic Stroke in a Hypertensive Population Based on Metabolomics and Lipidomics. Neuroscience. 2023 Nov 21;533:22-35.（SCI三区，IF=2.9）

24. Yuchen Ying, Shaoyi Lin, Fanqian Kong, Yuying Li, Shujun Xu, Xiaofeng Liang, Changyi Wang, Liyuan Han^*. Ideal Cardiovascular Health Metrics and Incidence of Ischemic Stroke Among Hypertensive Patients: A Prospective Cohort Study. Frontiers in Cardiovascular Medicine. 2020. doi:10.3389/fcvm.2020.590809.( SCI三区, IF=2.8)

25. Han Wang, Tian Zhao, Jingjing Zeng, Ruijie Zhang, Liyuan Pu, Suying Qian, Shan Xu, Yannan Jiang, Lifang Pan, Xiaoyu Dai, Xu Guo^*, Liyuan Han^*. Methods and clinical biomarker discovery for targeted proteomics using Olink technology. Proteomics Clin Appl. 2024 May 10:e2300233. （SCI四区，IF=2.1）

【编著】

1. 2023年，《宁波市民健康知识手册》，宁波出版社，副主编。

2. 2022年，《健康服务调查工具与方法》，人民卫生出版社，参编。

3. 2021年，《实用临床流行病学》，人民卫生出版社，主编。

4. 2020年，《EPIDEMIOLOGY》，浙江大学出版社，副主编。

5. 2020年，《MEDICAL STATISTICS》，浙江大学出版社，参编。

6. 2020年，《PREVENTIVE MEDICINE》，浙江大学出版社，参编。

7. 2020年，《疫苗与免疫》，人民卫生出版社，参编。

【专利】

1.慢性疾病决策支持可视化资源管理软件（2023SR0369127），计算机软件著作权，证书号：软著登字第10956298号，2023，第一。

2.一种脑卒中患者行走康复锻炼装置（ZL 2021 2 1014186.8），实用新型专利证书，证书号：第16076031号，2022，第一。

3.脑卒中康复辅助按摩床（ZL 2021 2 1016957.7），实用新型专利证书，证书号：第14867017号，2021，第一。

4.脑卒中智能远程问诊APP系统V1.0（2021SRE015961），计算机软件著作权，证书号：软著登字第E0078875号，2021，第一。

【获奖】

1.2021年获得“2020年度中国卒中学会优秀工作者”，授奖单位：中国卒中学会，第一。

2.2020年荣获宁波市科技进步二等奖，作品名称：基于前瞻性人群队列的缺血性脑卒中高危人群筛查与干预，授奖单位：宁波市科技局，第一。